Comparison of the middle ear fluid concentrations of the antibiotics with published MIC 90 s can provide a guide to the potential for bacterial eradication and also clinical success in acute otitis media [ 4 ]. The elimination half-life is about 3 h [ 9 — 12 ]. Ear discharge is also a late stage in the course of ASOM. In most cases of ASOM with ear discharge, the TM perforation is small or of pin-head size which will not allow topical ear drops, or spray, through. In contrast the concentration of azithromycin to the middle ear fluid is positively influenced by the cell content in the fluid. We are left with otomize usually as an alternative.
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A trial of treatment for acute otorrhea in children with tympanostomy tubes.
Amoxicillin middle ear fluid penetration and pharmacokinetics in children with acute otitis media.
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